However, in a recently published retrospective hospital-based report from India, unilateral disease was much higher at 36% and significantly more common among silent presenters compared to the clinically active group (33). Indexed in Web of Science, PubMed, MEDLINE, and Scopus. doi: 10.1001/archopht.1993.01090020051022, 38. 56. Read the latest articles of Frontiers in Neuroendocrinology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature No use, distribution or reproduction is permitted which does not comply with these terms. doi: 10.1097/MAJ.0b013e3182582330, 40. Moreover, disease severity is assessed similarly to bilateral disease, using clinically evaluated standardized tools, such as CAS (27) and Vision, Inflammation, Strabismus, Appearance (VISA) (28). doi: 10.1111/cen.14296, 4. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Diagnosing unilateral or asymmetric GO without any other signs of GO and especially in the absence of hyperthyroidism or high TRAb titer suggestive of Graves’ disease can be challenging (41) and requires increased clinical awareness and usually imaging of the orbits. ISSN: 0091-3022. doi: 10.1056/NEJMoa1012985, 44. Buescu A, Teixeira P, Coelho S, Donangelo I, Vaisman M. Orbital lymphoma misdiagnosed as Graves’ ophthalmopathy. Impact Factor 3.644 ... Frontiers in Endocrinology Cancer Endocrinology Toggle navigation Section (current) Section; ... Cuthbertson DJ and Pritchard DM (2020) Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center. Soroudi AE, Goldberg RA, McCann JD. Int Ophthalmol (2020). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). N Engl J Med (2011) 364:1920–31. The initial clinical characteristics of Graves’ orbitopathy vary with age and sex. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression. With an Impact Factor of 3.519 Frontiers in Endocrinology is the 4th most-cited open-access Endocrinology & Metabolism journal and ranks in top impact metrics FRONTIERS HOME ABOUT Ponto KA, Hommel G, Pitz S, Elflein H, Pfeiffer N, Kahaly GJ. In severe cases GO can be sight-threatening, thus requiring a prompt referral to specialist services (7) upon diagnosis. Such studies may provide further answers in regards to GO development and management. Cardiomyopathy is the leading cause of increased mortality in diabetes. Endocrinol. Clinical characteristics of moderate-to-severe thyroid associated ophthalmopathy in 354 Chinese cases. It is important to note that published studies have used different definitions of asymmetry and/or unilateral GO and this might explain the big variation in reported epidemiology among published data. Tu X, Dong Y, Zhang H, Su Q. Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis. doi: 10.1056/NEJMoa1910434, Keywords: asymmetry, Graves’ disease, exophthalmos, unilateral, hyperthyroidism, Citation: Panagiotou G and Perros P (2020) Asymmetric Graves’ Orbitopathy. In specific, small studies have suggested that euthyroid and primarily hypothyroid patients develop more asymmetrical GO (34, 35), which tends to present more mildly. doi: 10.1097/01.IOP.0000124675.80763.5A, 14. However, mechanical, vascular, and inflammatory factors as well as anatomical variances may contribute to development of asymmetric disease. There is a need for better documentation of the suggestions that asymmetric/unilateral GO might run a milder course or be a prelude to bilateral disease. Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients. Predictive score for the development or progression of Graves’ orbitopathy in patients with newly diagnosed Graves’ hyperthyroidism. Long-term multidisciplinary follow-up of unilateral thyroid-associated orbitopathy. Wiersinga WM, Bleumink M, Saeed P, Baldeschi L, Prummel MF. BackgroundHypophosphatasia is a rare bone disease characterized by impaired bone mineralization and low alkaline phosphatase activity. doi: 10.1530/eje.0.1480491, 32. Fox TJ, Anastasopoulou C. Graves Orbitopathy. Normal measurement of orbital structures: implications for the assessment of Graves’ ophthalmopathy. Endocrinology Impact Factor, IF, number of article, detailed information and journal factor. This year, 138 journals are listed in the category of Endocrinology & Metabolism in the 2016 edition of the Journal Citation Reports (JCR), of which 16 are open-access (OA).. Expression of lncRNA-HOTAIR in the serum of patients with lymph node metastasis of papillary thyroid carcinoma and its impact. Furthermore, previous studies have shown associations of asymmetric/unilateral GO with disease activity and severity and it is crucial that large cohorts include patients of different clinical status. Shyu VB, Hsu CE, Chen CH, Chen CT. 3D-assisted quantitative assessment of orbital volume using an open-source software platform in a Taiwanese population. However, some patients might exhibit asymmetric or unilateral symptoms, for yet unknown reasons. Chebib FS, Chamma AM. However, despite previous postulations the exact mechanisms remain elusive. However, the exact mechanisms causing asymmetry remain elusive. Most cited open-access journals in Endocrinology & Metabolism . doi: 10.3109/01676830903162841, 17. Facial asymmetry as an indicator of psychological, emotional, and physiological distress. Eur J Endocrinol (2008) 158:69–75. Psychosocial morbidity of Graves’ orbitopathy. However, there are no prospective data evaluating whether early selenium supplementation in asymmetric GO cases may halt progression to bilateral symptoms. Read the latest articles of Trends in Endocrinology & Metabolism at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature Impact Factor 3.644 ... Frontiers in Endocrinology Neuroendocrine Science Toggle navigation Section (current) Section; ... Sandoval D, Han X and Fujikawa T (2020) Leptin Receptors in RIP-Cre 25Mgn Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice. Is sleeping position related to asymmetry in bilateral Graves’ ophthalmopathy? If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. Another study however showed a linear negative correlation between proptosis and age between the ages of 31 and 80 (19), which was also confirmed independently (20). Ophthalmic Plast Reconstr Surg (2004) 20:224–5. Age-related changes in the normal sagittal relationship between globe and orbit. Endocrinol., 17 December 2020 N Engl J Med (2010) 362:726–38. doi: 10.1530/EJE-18-0039. Most importantly, longitudinal studies evaluating individuals who are at higher risk for developing bilateral symptoms as well as the effect of various treatments in impeding progression of unilateral and/or asymmetric disease to bilateral GO are warranted. Asymmetry of the human face is well documented (14, 15), while asymmetry in the orbital anatomy of normal human skulls has been shown to be the norm. Sheikh M, Abalkhail S, Doi SA, Al-Shoumer KA. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Herein, we review the literature on asymmetric GO and highlight its differences compared with bilateral GO. doi: 10.1371/journal.pone.0119589, 19. Clin Endocrinol (2020). Loop is the open research network that increases the discoverability and impact of researchers and their work. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. doi: 10.1097/OPX.0b013e3181890dc7, 22. doi: 10.1043/0003-3219(1978)048<0141:AAOAIT>2.0.CO;2, 16. 7. Australas Radiol (2007) 51:253–6. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. doi: 10.1007/s40618-020-01258-w, 13. Different studies have estimated prevalence of unilateral disease between 4.5 and 14% (13, 25, 29–31), while asymmetry was evident in 9–34% of patients with GO (13, 26, 32). Impact Factor 3.644 ... Diabetes is a specialty section of Frontiers in Endocrinology and Frontiers in Public Health. Ahmadi H, Shams PN, Davies NP, Joshi N, Kelly MH. doi: 10.1111/cen.13170, 47. Graves’ orbitopathy (GO) is the most common extrathyroidal feature of Graves’ disease (1) with an estimated prevalence of 10/10,000 persons in European populations (2), while more recent data have shown variable prevalence between 25% and over 50% in Graves’ hyperthyroidism cases (3) worldwide. doi: 10.1037/0022-3514.72.2.456, 18. and diplopia (3) being the most common features. More recently, in our multi-center prospective cohort recruiting 269 newly diagnosed patients from 13 different centers across Europe, we have found a prevalence of 30.9% for asymmetric and 10.7% for unilateral GO (12). Nat Rev Endocrinol (2020) 16:104–16. Mourits MP, Prummel MF, Wiersinga WM, Koornneef L. Clinical activity score as a guide in the management of patients with Graves’ ophthalmopathy. Laboratory and radiological … Oncol Lett (2020) 20(1):907–13. Im Vergleich zu historischen Journal Impact sank der Journal Impact 2019 von Frontiers in Endocrinology um 5.47 %. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. Front. Please enable Cookies and reload the page. J Pers Soc Psychol (1997) 72:456–66. In the present study, we investigated the effects of decorin (DCN) gene therapy on left ventricular function, cardiac inflammation and fibrosis in type 2 diabetes. Dolman PJ, Rootman J, Classification for Graves orbitopathy VISA. Therefore, more studies are needed to study asymmetric GO and shed light on the mechanisms leading to asymmetry. Type 2 diabetes was induced in male Wistar rats by high fat diet (HFD, 60% of calories as fat) and STZ (20 mg/kg, intraperitoneal). With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. Bartley GB. Indices of craniofacial asymmetry. Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, et al. Eur J Endocrinol (2011) 165:899–905. Am J Med Sci (2012) 344:418–21. Bilateral versus unilateral thyroid eye disease. Jang SY, Lee SY, Lee EJ, Yoon JS. doi: 10.1038/sj.eye.6701925, 23. In a study of 127 human skulls (254 orbits) of individuals aged between newborn to 76 years, asymmetry in orbital anatomy (greater horizontal diameter, greater vertical diameter, orbital perimeter and orbital base area) was present in all cases except four, with variability between 2.47 and 4.47% between the right and left orbit (16). In the future, mechanistic studies are needed to explore the underlying pathological processes in asymmetric/unilateral GO. PloS One (2015) 10:e0119589. However, whether unilateral and/or asymmetric disease represent a distinct variant of GO remains unclear and a better understanding of their underlying mechanisms may provide useful insight on the pathogenesis of GO, in general. Many risks factors have been associated with asymmetry. Asymmetry and/or unilateral GO can impose diagnostic challenges (13) and it is therefore important that awareness for asymmetric GO be raised. Loop is the open research network that increases the discoverability and impact of researchers and their work. BioMed Res Int (2018) 2018:4845894. doi: 10.1155/2018/4845894, 45. Elasticity of orbital septae or other local factors, associated with unilateral triggers such as infections or difference in potential for adipogenesis have also been suggested (12). Thyroid (2015) 25:942–8. The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. Older age, male sex, active and severe disease correlate with asymmetric disease. 11:589994. doi: 10.3389/fendo.2020.589994. Thyroid (2008) 18:541–4. doi: 10.1530/EJE-07-0450, 43. Kashkouli MB, Nojomi M, Parvaresh MM, Sanjari MS, Modarres M, Noorani MM. There is no contraindication in regards to any treatment modality including antithyroid drugs, radioactive iodine, and/or total thyroidectomy for mild asymmetric and/or unilateral GO, while in moderate to severe cases radioiodine should be avoided, similarly to bilateral symmetric disease (42). Normal values of hertel exophthalmometry in children, teenagers, and adults from Tehran, Iran. Eckstein AK, Losch C, Glowacka D, Schott M, Mann K, Esser J, et al. Smoking cessation advice and restoring the euthyroid state are important pillars in the management of asymmetric GO. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. It was established in 2010 and is published by Frontiers Media, who was included on Jeffrey Beall's now-defunct list of "potential, possible, or probable predatory publishers". Laurberg P, Wallin G, Tallstedt L, Abraham-Nordling M, Lundell G, Torring O. TSH-receptor autoimmunity in Graves’ disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. Thyroid (2017) 27:1475–80. Efficacy and safety of mycophenolate mofetil in patients with active moderate-to-severe Graves’ orbitopathy. Taylor PN, Zhang L, Lee RWJ, Muller I, Ezra DG, Dayan CM, et al. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. • Unilateral GO is likewise variably defined as one or more features in one eye without any such manifestations in the other eye (20), proptosis >2 mm in one eye with normal examination of the other eye (25), or proptosis difference between eyes >4 mm, and/or if clinical signs and symptoms of GO found unilaterally (26). With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. Others have examined the effect of sleeping position but found no significant correlation with asymmetric GO (32). A 48-year-old woman was admitted to our hospital because of moon face and edema. Furthermore, less is known in regards to the epidemiology of unilateral or asymmetric GO in children. Perros P, Zarkovic MP, Panagiotou GC, Azzolini C, Ayvaz G, Baldeschi L, et al. Moura Neto A, Denardi FC, Delamain MT, Tambascia MA, Vassallo J, Caldato R, et al. Graves’ orbitopathy as a rare disease in Europe: a European Group on Graves’ Orbitopathy (EUGOGO) position statement. Frontiers in Endocrinology publishes rigorously peer-reviewed research from basic molecular and cellular communication to clinical care, advancing our understanding of the endocrine system, and leading to novel therapies for some of the most prevalent health issues such as obesity, diabetes, reproduction and aging.. Wiersinga WM, Smit T, van der Gaag R, Mourits M, Koornneef L. Clinical presentation of Graves’ ophthalmopathy. Clinicians involved in the care of patients with GO need to be able to identify unilateral or asymmetric GO, as timely recognition of asymmetry may expedite referral to specialist services and facilitate further management. doi: 10.4103/0301-4738.83612, 21. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. GO is closely associated with thyroid autoimmunity, and although it is classically linked with hyperthyroidism, GO features have been described in hypothyroid or euthyroid individuals (4). Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, et al. Wide agreement and consensus among experts on the definition of asymmetry and unilaterality is paramount and will facilitate diagnosis, management, and research into this fascinating clinical entity. Eur J Endocrinol (2003) 148:491–5. here. In another study, male subjects exhibited asymmetric disease (proptosis and overall asymmetry) three-fold more frequently compared with women, while women with hyperthyroidism demonstrated more symmetry compared with euthyroid and hypothyroid individuals of either sexes (23). Cloudflare Ray ID: 6044941f696532aa Completing the CAPTCHA proves you are a human and gives you temporary access to the web property. Immunity (2020) 52:275–94.e279. Asymmetry indicates more severe and active disease in Graves’ orbitopathy: results from a prospective cross-sectional multicentre study. Frontiers in Neuroendocrinology Impact Factor IF 2020|2019|2018 - BioxBio Bahn RS. Kahaly GJ, Petrak F, Hardt J, Pitz S, Egle UT. Ye X, Bo X, Hu X, Cui H, Lu B, Shao J, et al. In conclusion, although the available literature is limited, asymmetric and/or unilateral GO tend to be present in older age and male patients and is associated with more active and severe GO. In fact, TRAb titer together with smoking, duration of thyroid dysfunction and clinical activity score (CAS) at baseline are regarded as main risk factors for developing GO (6). Orphanet J Rare Dis (2017) 12:72. doi: 10.1186/s13023-017-0625-1, 3. Impact Factor 3.644 | CiteScore 3.4More on impact ›, Mechanisms and Novel Therapies in Graves’ Orbitopathy: Current Update The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. N Engl J Med (2020) 382:341–52. Journal Impact 2018 di Frontiers in Endocrinology è 3.630 (Ultimi dati nel 2019). Tsai CC, Kau HC, Kao SC, Hsu WM. All authors contributed to the article and approved the submitted version. Ophthalmic plastic and reconstructive surgery. Eye (2006) 20:569–73. 11:611845. doi: 10.3389/fendo.2020.611845. Shackelford TK, Larsen RJ. Another way to prevent getting this page in the future is to use Privacy Pass. Prevalence of thyroid eye disease in Graves’ disease: A meta-analysis and systematic review. It has been suggested that unilateral GO may progress to bilateral disease (11) and we have also found that asymmetry was associated with more severe and active GO (12). Salvi M, Vannucchi G, Campi I, Rossi S, Bonara P, Sbrozzi F, et al. Decompression surgery may be used in appropriate cases. For more severe cases, methylprednisolone infusion (44) and/or administration of immune-modifying therapies, such as rituximab (45) and/or mycophenolate mofetil (46) may need to be considered. Definitions of asymmetric disease asymmetry in itself can be sight-threatening, thus requiring a prompt referral to services... To bilateral symptoms and Frontiers in Endocrinology is the 2nd most cited open-access in! Correlate with asymmetric disease P, Okosieme O, et al characterized by impaired bone mineralization and alkaline. 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En 2020 ) one patient unresponsive to steroid immunosuppression normal measurement of orbital structures implications... Sk, Jain N, Saraf S, doi SA, Al-Shoumer KA rare disease in Europe: European. Go cases may cause blindness is sleeping position but found no significant correlation with asymmetric GO be raised orbitopathy patients., Ng CH, Lee RWJ, Muller I, Ezra DG, Dayan CM, al. Values of hertel exophthalmometry in children MS, Modarres M, Wang T, van der Gaag,! To our hospital because of moon face and edema to specialist services 7. Research network that increases the discoverability and Impact of researchers and their work on!, Bystrom K, Torring O, et al prompt referral to specialist (!